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KMID : 0043319970200040375
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Archives of Pharmacal Research
1997 Volume.20 No. 4 p.375 ~ p.378
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Chongmyungtang Attenuates Kainic Acid-induced Seizure and Mortal Effect in the Mouse
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Jang Kyung-Jin
Lee Kyou-Heung
Kim Sang-Lin
Park Dong-Young
Park Beom-Kyu
Lim Doo-Hyung
Cho Yong-Joon
Jhoo Wang-Kee
Kim Hyoung-Chun
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Abstract
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The Chongmyungtang (CMT; the combination of Acorus gramineus, polygala tenuifolia and Poria cocos) has been recognized to possess the preventive effect against several neurologic disorders in human. In this study, we examined the effect of CMT on the three parameters associated with kainic acid (KA)-induced neurotoxicities; seizure/mortality, increased fos-related antigen (FRA) and glial fibrillary acidic protein (GFAP) expression. KA induced vigorous convulsions lasting 4-6 hr. Pretreatments with CMT before KA injection significantly reduced the seizure intensity as well as the mortality. CMT pretreatments also attenuated the KA-induced increase in FRA/GFAP expression in the hippocampus. These results suggest that CMT has a neuroprotective effect against KA-induced neurotoxicities.
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KEYWORD
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Chongmyundtang, Neuroprotective effect, Kainic acid-induced neurotoxicity
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